Mutations

Changes in the coding sequence of genes

Fine Structure Mutations -

• Silent Mutation

AUG.UUU.AGG.GGG.............UGG.UGA - DNA/RNA
MET.PHE.ARG.GLY..............TRP.STOP - PROTEIN:

Mutation (U to C)
AUG.UUC.AGG.GGG.............UGG.UGA
MET.PHE.ARG.GLY............TRP.STOP

• Missense

AUG.UUU.AGG.GGG.............UGG.UGA
MET.PHE.ARG.GLY............TRP.STOP

Mutation (G to A)
AUG.UUU.AAG.GGG.............UGG.UGA
MET.PHE.LYS .GLY..............TRP.STOP

• Non Sense Mutations

DNA: AUG.UUU.AGA.GGG.............UGG.UGA
PRO: MET.PHE.ARG.GLY............TRP.STOP
Mutation (A to U)
DNA: AUG.UUU.UGA.GGG.............UGG.UGA
PRO: MET.PHE.Stop

• Frame Shift Mutations

AUG.UUU.AGG.GGG.............UGG.UGA
MET.PHE.ARG.GLY............TRP.STOP
Insertion of an A
AUG.UAU.UAG.GGG.G.............UG.GUG.A
MET.TYR.STOP....
 

AUG.UUU.AGG.GGG.............UGG.UGA
MET.PHE.ARG.GLY............TRP.STOP
Deletion of a G
AUU.UUA.GGG.GG.............U.GGU.GA
ILE.LEU.GLY.GLY.... GLY.(SER,ARG?)

by Kenneth G. Wilson,
Professor of Botany
Miami University
wilsonkg@muohio.edu