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Repeating Co-polymers

H. Gobind Khorana was able to synthesize small repeating nucleotides for use in these experiments. Polynucleotide Phosphorylase would also link di-, tri-, and tetra-nucleotides together to form repeating copolymers

Repeatin g Sequenc e

Polynucleotides

Repeating Triplets

UG

UGUGUGUGUGUGUGUGUGUGUG

UGU
GUG

UUG

UUGUUGUUGUUGUUGUUGUUG

UUG
UGU
GUU

UACG

UACGUACGUACGUACGUACGUACG

UAC
GUA
CGU
ACG

 

Repeating Copolymer

Codons Produced

Amino Acids in Polypeptide

UG

UGU
GUG

Cysteine
Valine

AC

ACA
CAC

Threonine
Histidine

UUC

UUC
UCU
CUU

Phenylalanine
Serine
Leucine

AUC

AUC
UCA
CAU

Isoleucine
Serine
Histidine

UAC

UAU
CAU
UCU
AUC

Tyrosine
Leucine
Serine
Isoleucine

GAUA

GAU
AGA
UAG
AUA

None

Note: that this is one of the independent proofs of the triplet code. The other proof was from Francis Crick.

 

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This web site is provided for instruction in Botany and Zoology 342 or Genetics 342

Text: Genetics: A conceptural ApproachBenjamin A Pierce

This is our friend Oliver the parrotlet, a true parrot, the smallest in the world.


 

by Kenneth G. Wilson,
Professor of Botany
Miami University
wilsonkg@muohio.edu