Heat - detector is an Calcium ion channel - isolated using capsaicin binding

 

Cold receptor - Menthol binding

David D. McKemy, Werner M. Neuhausser, David Julius
SUMMARY: The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use... CONTEXT: ...52 °C (refs 3-5). Insights into the mechanisms of heat sensation have come from molecular cloning of the vanilloid receptor (VR1), an excitatory ion channel on sensory neurons that is activated by temperatures exceeding 43 °C, and......
Nature416, 52 - 58 (07 Mar 2002) Article

Menthol

 

Heat shock