Chromosome Structure
The DNA in the eukaryotic cell is organized into a chromosome.
There is a single strand of DNA running the whole length of the chromosome
Histones are basic proteins found associated with nucleic acids.
Core histone - DNA complex
The DNA is wound around histones forming beads on a string
Nucleosomes are wound to form Solenoids .
Solenoids are linked to scaffold proteins
Location of Scafold Associated Regions or SARS on the map
SARs mapped in Drosophila
Dispersive model for nucleosome distribution at the replication fork.
Chromosomes are readily visible during metaphase of Mitosis
They are arranged based on size and centromere location.
Human chromosomes 1 and X
Chromosome Isolation
Chromosome Painting
Chromosome - Detail Structure
The sequence of the DNA in Yeast Centromeres has been determined.
Centromere and spindle fiber microtubule
Chromatids, Centromere, and Spindle Fiber.
Problems near the end. How do we keep from loosing DNA on the lagging strand?
Telomeres. Could telomerase may be Ponce DeLeon's fountain of youth?
This web site is provided for instruction in Botany and Zoology 342
by Kenneth G. Wilson,
Professor of Botany
Miami University
wilsonkg@muohio.edu
